What is Hochu-Ekki-To
While the cause of many cancers remains unknown, surgical interventions trigger certain forms. Bile duct surgery, for example, often leads to the delayed appearance of biliary cancer. Herbal drugs may prevent such cancer from developing. A 2009 paper in the “Journal of Surgical Research” looked at the impact of the Japanese supplement hochu-ekki-to on an animal model of bile duct cancer. Hamsters received daily doses of this herbal medication for 22 weeks. Relative to controls, hamsters given hochu-ekki-to showed a 50 percent reduction in bile cancer. Similar results, however, may not be obtained in tests with human subjects.
The rats were orally administered Hochu-ekki-to, Ninjin-youei-to (100 and 300 mg/kg/day) or Sho-saiko-to (300 mg/kg/day) 5 days per week. Serum and liver samples were obtained 2 days after the last porcine serum injection. Hochu-ekki-to and Ninjin-youei-to showed significant suppressive effects on the increase in hepatic hydroxyproline, namely total collagen. Further, Ninjin-youei-to significantly suppressed the increases of type IV collagen localized in the basement membrane and prolyl 4-hydroxylase, a collagen synthesis enzyme, in serum or liver. Hochu-ekki-to showed a similar trend. Although Sho-saiko-to did not significantly suppress the increase in hepatic hydroxyproline, it intensely suppressed serum type IV collagen.